[Two-year follow-up of pulmonary arterial hypertension patients treated with sildenafil].
| Autor: | Franchi SM; Instituto do Coração, São Paulo, SP, Brasil., Barreto AC, Cícero C, Castro CR, Ribeiro ZV, Lopes AA |
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| Jazyk: | portugalština |
| Zdroj: | Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2010 May; Vol. 94 (5), pp. 671-7. Date of Electronic Publication: 2010 Apr 30. |
| DOI: | 10.1590/s0066-782x2010005000041 |
| Abstrakt: | Background: The long-term effects of drugs developed for the control of pulmonary arterial hypertension (PAH) are little known, since multicenter studies usually last 12 to 16 weeks. Objective: To evaluate the two-year outcome of PAH patients receiving monotherapy with sildenafil (a phosphodiesterase-5 inhibitor), with regard to their functional capacity. Methods: Twenty four patients (ages between 8 and 54 years) with idiopathic PAH (IPAH, n = 9) or congenital heart disease-associated PAH (CHD-PAH, n = 15) were treated with sildenafil for two years, with daily oral doses ranging from 60 to 225 mg (tid). Physical capacity was assessed by the distance walked in the 6-minute walk test (DW6M) and by the degree of dyspnea at the end of the walk (Borg scale); peripheral oxygen saturation was also recorded (SpO(2)6M, pulse oximetry). Results: In the 18 patients who completed the two-year follow-up, there was a progressive and sustained increase in DW6M, both in the IPAH group (from 239 +/- 160 m to 471 +/- 66 m, p = 0.0076) and in the CHD-PAH group (from 361 +/- 144 m to 445 +/- 96 m, p = 0.0031), with improvement of dyspnea at the end of the walk (p<0.05 for both groups). No decrease in SpO(2)6M was observed in the groups; in patients with CHD-PAH, in particular, SpO(2)6M went from 77 +/- 20% to 79 +/- 16% (p = 0.5248). Five deaths occurred (three in the IPAH group) and one patient was lost to follow-up during the study period. Conclusion: In a two-year follow-up, sildenafil proved useful in the control of the functional status of PAH patients, with significant improvement in both groups considered. |
| Databáze: | MEDLINE |
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