[Effect of the simvastatin in abdominal sepsis of diabetic rats].

Autor:	Araújo-Filho I; Departamento de Cirurgia, Universidade Federal do Rio Grande do Norte, Natal, Brasil., Jácome DT, Rêgo AC, Azevedo IM, Egito ES, Medeiros AC
Jazyk:	portugalština
Zdroj:	Revista do Colegio Brasileiro de Cirurgioes [Rev Col Bras Cir] 2010 Feb; Vol. 37 (1), pp. 39-44.
DOI:	10.1590/s0100-69912010000100009
Abstrakt:	Objective: Infection and sepsis are major causes of morbidity and mortality after surgery of diabetic patients. Statins have been shown to exhibit anti-inflammatory and immunomodulatory (pleiotropic) effects, independent of lipid lowering. This study aimed to observe whether the pretreatment with simvastatin in a cecal ligation and perforation model of sepsis is beneficial in diabetic rats. Methods: Fifty six Wistar rats were randomly assigned to non-diabetic group (n=28), and streptozotocin-induced diabetic group (n=28). Abdominal sepsis was induced in 14 diabetic and in 14 non diabetic rats and the other 28 rats were allocated on sham group. Sepsis rats and sham rats (each with 7 animals) were treated with oral simvastatin (20 mg kg-1 day-1) or normal saline solution 0.9%. Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were tested in all the animals. Statistical analysis was done by ANOVA and Tukey test, with p<0.05. Results: Simvastatin reduced mortality in diabetic rats. Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were lower in diabetic and non diabetics septic rats treated with simvastatin, than after saline treatment. Conclusion: Simvastatin showed anti-inflammatory effect, which could play some protection against the progress of sepsis in diabetic rats.
Databáze:	MEDLINE
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