| Autor: |
Oshima N; Division of Gastric Surgery, Shizuoka Cancer Center., Tanizawa Y, Bando E, Kawamura T, Tokunaga M, Sugisawa N, Taki Y, Motegi Y, Boku N, Sasaki K, Terashima M |
| Jazyk: |
japonština |
| Zdroj: |
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2010 Apr; Vol. 37 (4), pp. 697-701. |
| Abstrakt: |
A 59-year-old male was found to have advanced gastric cancer with multiple lymph node metastasis including para-aortic lymph nodes(cT3, cN3, cM0, cH0, cP0, cStage IV). Since curative surgery was deemed not feasible, we tried neoadjuvant chemotherapy expecting downstaging of the tumor. S-1(120 mg/body)was orally administered for three weeks followed by one week rest, and CDDP(60 mg/m2)was administered on day 8. Three courses of treatment resulted in a marked shrinkage of the primary lesion and a reduction of lymph nodes. He was judged as clinical PR by RECIST, and a radical resection was considered possible. Laparotomy revealed neither ascites nor peritoneal dissemination, and he underwent total gastrectomy, splenectomy and D2+para-aortic lymph node dissection with curative intent. The histological diagnosis revealed complete disappearance of cancer cells in the primary lesion of the stomach and lymph nodes, confirming a pathological complete response. The patient has been alive for six months without recurrence. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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