| Autor: |
Epstein OI; Materia Medica Holding, Moscow, Russia., Sergeeva SA, Dugina YL, Andrianov VV, Gainutdinova TKh, Ismailova AI, Muranova LN, Gainutdinov KhL |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2009 Nov; Vol. 148 (5), pp. 754-7. |
| DOI: |
10.1007/s10517-010-0809-3 |
| Abstrakt: |
We studied the effects of preliminary administration of haloperidol in low doses on changes in motor activity of edible snail and in electrical properties of defensive behavior command neurons induced by chronic administration of haloperidol. The rate of locomotion decreased after injections of haloperidol preparations (C6, C12, C30, C200 and a mixture C12+C30+C200) for 3 days. Similar changes were observed after 3 days of haloperidol administration. Haloperidol preparations in low doses produced a modulating effect on the decrease in locomotion rate and hyperpolarization of command neurons in edible snails caused by chronic exposure to haloperidol: the decrease in locomotion rate caused by chronic haloperidol treatment was prevented by preliminary injection of haloperidol in low doses C6, C12 and C30; the depolarizing shift of command neuron membrane potential was also abolished after consecutive injection of the same haloperidol preparations C6, C12 and C30. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink