| Autor: |
Westbrook SD; Department of Dental Diagnostic Sciences, Division of General Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA. westbrooks@uthscsa.edu, Wiederhold NP, Vallor AC, Kotara S, Bernardo S, Lee SA, Kirkpatrick WR, Toro JJ, Freytes C, Patterson TF, Redding SW |
| Jazyk: |
angličtina |
| Zdroj: |
Medical mycology [Med Mycol] 2010 May; Vol. 48 (3), pp. 557-60. |
| DOI: |
10.3109/13693780903213504 |
| Abstrakt: |
We report a case of fluconazole-resistant oropharyngeal colonization caused by a strain of Candida glabrata that rapidly regained susceptibility once prophylaxis with this agent was discontinued and echinocandin therapy was initiated. Isolates collected before and after discontinuation of fluconazole were confirmed to be isogenic by RAPD analysis. Transcription analysis demonstrated constitutive expression of genes encoding efflux pumps in the isolate recovered on fluconazole prophylaxis and transient expression in those isolates collected after fluconazole was discontinued. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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