| Autor: |
Chang JL; University of Washington, Seattle, Washington, USA., Chen G, Ulrich CM, Bigler J, King IB, Schwarz Y, Li S, Li L, Potter JD, Lampe JW |
| Jazyk: |
angličtina |
| Zdroj: |
Nutrition and cancer [Nutr Cancer] 2010; Vol. 62 (3), pp. 329-35. |
| DOI: |
10.1080/01635580903407106 |
| Abstrakt: |
Epidemiologic studies have examined the association between fruit and vegetable (F&V) consumption and the risk of cancer. Several cancer-preventive mechanisms have been proposed, such as antioxidant properties and modulation of biotransformation enzyme activities; both may be associated with reducing DNA damage and hence the mutation rate. We investigated, in a randomized, controlled, crossover feeding trial, the effect of 10 servings/day of botanically defined F&V for 2 wk on endogenous DNA damage; resistance to gamma -irradiation damage; and DNA repair capacity in lymphocytes, measured by the Comet assay. We also explored the association between the UGT1A1*28 polymorphism and serum bilirubin concentrations and DNA damage and repair measures. Healthy men (n = 11) and women (n = 17), age 20 to 40 yr, provided blood samples at the end of each feeding period. Overall, F&V did not affect DNA damage and repair measures in lymphocytes. The number of UGT1A1*28 alleles was inversely associated with sensitivity to gamma -irradiation exposure and DNA repair capacity, but a biological mechanism to explain this association is unclear. A larger sample size is needed to investigate the association between bilirubin concentrations and endogenous DNA damage. With inconsistent findings in the literature, additional dietary intervention studies on the effect of F&V on DNA damage and repair are needed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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