[Analysis of safety and effects on the oral whole cell/recombinant B subunit cholera vaccine in university students and workers].

Autor:	Shi NM; Center of Disease Control and Prevention, Chaoyang District, Beijing 100021, China. shinianmin@sina.com, Luo FJ, Li SM, Bai YH, Qu Y, Song X
Jazyk:	čínština
Zdroj:	Zhonghua yi xue za zhi [Zhonghua Yi Xue Za Zhi] 2010 Jan 19; Vol. 90 (3), pp. 192-5.
Abstrakt:	Objective: To evaluate the safety, immunogenicity and protective efficiency of the oral whole cell/recombinant B subunit cholera vaccine in Beijing Olympic volunteers and workers. Method: Analyzing the incidence rate of adverse reaction and Protective Rate (PR) after taking the vaccine in Olympic volunteers in 6 universities in Beijing; comparing the anti-cholera toxin (CT) detected with ELISA prior and after taking the vaccine in Olympic workers. Results: The total rate of adverse reaction of Olympic volunteers was 0.38%; the main side effects were gastrointestinal symptoms, such as bellyache and diarrhea which were mild and temple; the acute diarrhea incidence rate of Olympic volunteers after taking the vaccine was significantly lower than those not taking it, the PR was 76.27%; the positive rate of anti-CT of Olympic workers after taking the vaccine was significantly higher than those before taking it, the levels of anti-CT titers declined after 6 months since they had taken the vaccine. Conclusion: The results from above two observed population indicate that the oral rBS-WC cholera vaccine is efficient and safe.
Databáze:	MEDLINE
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