Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks.
| Autor: | Rodríguez-Martínez AB; Department of Animal Health, Neiker-Tecnalia, Derio, Bizkaia, Spain., Garrido JM, Maza S, Benedicto L, Geijo M, Gómez N, Minguijón E, Benestad SL, Juste RA |
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| Jazyk: | angličtina |
| Zdroj: | BMC veterinary research [BMC Vet Res] 2010 Mar 26; Vol. 6, pp. 17. Date of Electronic Publication: 2010 Mar 26. |
| DOI: | 10.1186/1746-6148-6-17 |
| Abstrakt: | Background: Since 2002, an active surveillance program for transmissible spongiform encephalopathy in small ruminants in European Union countries allowed identification of a considerable number of atypical cases with similarities to the previously identified atypical scrapie cases termed Nor98. Case Presentation: Here we report molecular and neuropathological features of eight atypical/Nor98 scrapie cases detected between 2002 and 2009. Significant features of the affected sheep included: their relatively high ages (mean age 7.9 years, range between 4.3 and 12.8), their breed (all Latxa) and their PRNP genotypes (AFRQ/ALRQ, ALRR/ALRQ, AFRQ/AFRQ, AFRQ/AHQ, ALRQ/ALRH, ALRQ/ALRQ). All the sheep were confirmed as atypical scrapie by immunohistochemistry and immunoblotting. Two cases presented more PrP immunolabelling in cerebral cortex than in cerebellum. Conclusions: This work indicates that atypical scrapie constitutes the most common small ruminant transmissible spongiform encephalopathy form in Latxa sheep in the Spanish Basque Country. Moreover, a new genotype (ALRQ/ALRH) was found associated to atypical scrapie. |
| Databáze: | MEDLINE |
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