| Autor: |
Bhavnani BR; Department of Obstetrics and Gynaecology, St. Michael's Hospital, Toronto, Ontario, Canada., Gerulath AH |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 1991 Apr; Vol. 38 (4), pp. 433-9. |
| DOI: |
10.1016/0960-0760(91)90331-x |
| Abstrakt: |
One of the main components of conjugated equine estrogens is equilin sulfate and this estrogen in postmenopausal women is metabolized to 17 beta-dihydroequilin, 17 beta-dihydroequilenin and equilenin. To investigate the possibility that some of these estrogens may be formed directly in the target tissues, we studied the in vitro metabolism of [3H]equilin in various types of normal and malignant human endometrium, including adenocarcinoma grown in athymic nude mice. The results indicate that normal and neoplastic human endometrium can form the above three metabolites. The highest level of 17 beta-reduced products were isolated from the normal secretory endometrium. Equilenin was the most abundant metabolite isolated from both the normal and malignant endometrium. The formation of [3H]equilenin indicates the presence of a 6,8(9) steroid dehydrogenase-isomerase in the human endometrium. The formation of 17 beta-dihydroequilin in the endometrium may be of importance as this estrogen is 8 times more potent as a uterotrophic agent than equilin and estrone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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