Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss.

Autor: Spieles-Engemann AL; Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA., Behbehani MM, Collier TJ, Wohlgenant SL, Steece-Collier K, Paumier K, Daley BF, Gombash S, Madhavan L, Mandybur GT, Lipton JW, Terpstra BT, Sortwell CE
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2010 Jul; Vol. 39 (1), pp. 105-15. Date of Electronic Publication: 2010 Mar 20.
DOI: 10.1016/j.nbd.2010.03.009
Abstrakt: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson's disease (PD). However, the impact of STN-DBS on the progression of PD is unknown. Previous preclinical studies have demonstrated that STN-DBS can attenuate the degeneration of a relatively intact nigrostriatal system from dopamine (DA)-depleting neurotoxins. The present study examined whether STN-DBS can provide neuroprotection in the face of prior significant nigral DA neuron loss similar to PD patients at the time of diagnosis. STN-DBS between 2 and 4 weeks after intrastriatal 6-hydroxydopamine (6-OHDA) provided significant sparing of DA neurons in the SN of rats. This effect was not due to inadvertent lesioning of the STN and was dependent upon proper electrode placement. Since STN-DBS appears to have significant neuroprotective properties, initiation of STN-DBS earlier in the course of PD may provide added neuroprotective benefits in addition to its ability to provide symptomatic relief.
((c) 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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