Identification and characterization of novel hepatitis B virus subgenotype C10 in Nusa Tenggara, Indonesia.

Autor: Mulyanto; Immunobiology Laboratory, Faculty of Medicine, University of Mataram, Mataram, Indonesia., Depamede SN, Surayah K, Tjahyono AA, Jirintai, Nagashima S, Takahashi M, Okamoto H
Jazyk: angličtina
Zdroj: Archives of virology [Arch Virol] 2010 May; Vol. 155 (5), pp. 705-15. Date of Electronic Publication: 2010 Mar 20.
DOI: 10.1007/s00705-010-0628-x
Abstrakt: Six novel subgenotypes (B7, B8, C6, C8, C9, and D6) within three hepatitis B virus (HBV) genotypes (B-D) were recently identified in Indonesia. To further characterize HBV in this country, 18 HBV-viremic samples obtained from blood donors in Nusa Tenggara, Indonesia, were subjected to phylogenetic analysis of an 1.6-kb partial or full-length sequence. Thirteen HBV isolates were classified into genotype B with four distinct subgenotypes [B3 (n = 2), B5 (n = 1), B7 (n = 4), and B8 (n = 6)], followed by 4 HBV isolates of genotype C (HBV/C); the remaining one isolate was of D (D1). As for the four HBV/C isolates, one isolate segregated into subgenotype C1, and two into C2. The remaining HBV/C isolate [C0901177(NT3)] differed from reported HBV/C isolates (C1-C9) by 4.6-7.7% over the entire genome and did not show evidence of recombination with any of the known HBV genotypes/subgenotypes, justifying its conclusive assignment into a novel subgenotype (C10) within genotype C.
Databáze: MEDLINE
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