A histopathologic comparison between synchronous and single primary oral squamous cell carcinomas.

Autor: Dissanayaka WL; Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka., Jayasooriya PR, Kumarasiri PV, Tilakaratne WM
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2010 May; Vol. 109 (5), pp. 732-8. Date of Electronic Publication: 2010 Mar 20.
DOI: 10.1016/j.tripleo.2009.12.012
Abstrakt: Objective: This study compares synchronous oral squamous cell carcinomas (OSCCs) with single primary OSCCs to assess the histopathologic parameters with a known prognostic significance.
Study Design: Twenty-eight cases of synchronous OSCCs and a control group of single primary OSCCs were compared for 15 histologic prognostic variables.
Results: Results showed significantly less amount of abnormal mitoses (synchronous-1: P = .002; synchronous-2: P = .006) and tumor-induced stroma (synchronous-1: P = .011; synchronous-2: P = .001) in synchronous OSCCs than in single primary OSCCs. Depth of invasion was considerably lower in synchronous OSCCs than in single primary OSCCs (synchronous-1: P = .007; synchronous-2: P = .002). Lymph node metastasis (synchronous-1: P = .051; synchronous-2: P = .051) was found to be rare in synchronous OSCCs compared with single primary OSCCs.
Conclusion: Synchronous OSCCs show less aggressive histopathologic features than single primary OSCCs.
(Copyright (c) 2010 Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
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