Severe exfoliative dermatitis caused by strontium ranelate: two cases of a new drug reaction.

Autor: Smith EV; Dermatology, Singleton Hospital, Sketty Lane, Swansea SA2 8QA, UK. dremmasmith@doctors.org.uk, Shipley DR
Jazyk: angličtina
Zdroj: Age and ageing [Age Ageing] 2010 May; Vol. 39 (3), pp. 401-3. Date of Electronic Publication: 2010 Mar 17.
DOI: 10.1093/ageing/afq026
Abstrakt: Strontium ranelate is a relatively new drug used as a second-line treatment for osteoporosis, often targeted at older patients. It is known to cause skin rash and rarely drug reaction with eosinophilia and systemic symptoms, but there are no reports of exfoliative dermatitis as a reaction in the literature. We present the first two cases of this adverse effect of the drug, combined with eosinophilia but no systemic symptoms. We illustrate the significant morbidity involved and use of systemic steroid treatment required, highlighting the need for awareness of this reaction in medical and particularly in elderly care communities.
Databáze: MEDLINE