| Autor: |
Ajibola ES; College of Veterinary Medicine, University of Agriculture, Abeokuta, Nigeria. esajibola@yahoo.com, Adebayo AO, Thomas FC, Rahman SA, Gbadebo AM, Odunbaku TA |
| Jazyk: |
angličtina |
| Zdroj: |
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2009 Dec; Vol. 24 (2), pp. 107-10. |
| DOI: |
10.4314/njps.v24i2.52917 |
| Abstrakt: |
The study was designed to investigate the nature of the cholinoceptors at the sciatic nerve-gastrocnemius muscle junction of the common African toad (Bufo regularis). Using myographic technique, the twitch properties of the sciatic-gastrocnemius muscle preparation of the common African toad was studied. Both the twitch height and peak tetanic height were measured as a percentage of control. Hexamethonium at a concentration of 0.1 mM significantly [P<0.05] reduced the mean twitch height from 2.62 cm to 1.0 cm and mean peak tetanic height from 5.38 cm to 4.32 cm. Hexamethonium, however does not produce tetanic fade at the same concentration. We hypothesized that the cholinoceptors of the neuromuscular junction of the common African toad (Bufo regularis) resemble the developing synapse of African clawed toad (Xenopus laevis) and may contain muscarinic M1 autoreceptors at the pre juntional membrane. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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