2,5-Disubstituted pyridines as potent GPR119 agonists.
| Autor: | Wu Y; GlaxoSmithKline, Research Triangle Park, NC 27709, USA. yulin.x.wu@gsk.com, Kuntz JD, Carpenter AJ, Fang J, Sauls HR, Gomez DJ, Ammala C, Xu Y, Hart S, Tadepalli S |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Apr 15; Vol. 20 (8), pp. 2577-81. Date of Electronic Publication: 2010 Feb 25. |
| DOI: | 10.1016/j.bmcl.2010.02.083 |
| Abstrakt: | A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor. (Copyright 2010 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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