Obesity among HIV-infected persons: impact of weight on CD4 cell count.

Autor: Crum-Cianflone NF; Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA., Roediger M, Eberly LE, Vyas K, Landrum ML, Ganesan A, Weintrob AC, Barthel RV, Agan BK
Jazyk: angličtina
Zdroj: AIDS (London, England) [AIDS] 2010 Apr 24; Vol. 24 (7), pp. 1069-72.
DOI: 10.1097/QAD.0b013e328337fe01
Abstrakt: To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P = 0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.
Databáze: MEDLINE