| Autor: |
Oga S; Departamento de Farmacologia do Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil., Taniguchi SF, Najjar R, Souza AR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of inorganic biochemistry [J Inorg Biochem] 1991 Jan; Vol. 41 (1), pp. 45-51. |
| DOI: |
10.1016/0162-0134(91)85008-5 |
| Abstrakt: |
The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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