Chemical characterization of Lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice.

Autor: Wu HT; Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province, PR China., He XJ, Hong YK, Ma T, Xu YP, Li HH
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2010 Jun; Vol. 46 (5), pp. 540-3. Date of Electronic Publication: 2010 Mar 01.
DOI: 10.1016/j.ijbiomac.2010.02.010
Abstrakt: In this study, we investigated chemical structure of Lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The Lycium barbarum polysaccharides had IR bands at 800-1200 cm(-1), 1450-1800 cm(-1), 2500-3000 cm(-1), and 3200-3600 cm(-1), which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (P<0.01) compared to normal control mice. Administration of Lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (P<0.01) compared to model group.
(Copyright 2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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