| Autor: |
Cho MH; Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK |
| Jazyk: |
angličtina |
| Zdroj: |
Nature genetics [Nat Genet] 2010 Mar; Vol. 42 (3), pp. 200-2. Date of Electronic Publication: 2010 Feb 21. |
| DOI: |
10.1038/ng.535 |
| Abstrakt: |
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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