Outcomes of laser thermal therapy for recurrent head and neck cancer.

Autor: Sercarz JA; Department of Surgery, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA., Bublik M, Joo J, Paiva PB, Areco KN, Brandalise MH, Loh C, Masterman-Smith M, Paiva MB
Jazyk: angličtina
Zdroj: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2010 Mar; Vol. 142 (3), pp. 344-50.
DOI: 10.1016/j.otohns.2009.11.019
Abstrakt: Objective: To review the outcomes of a phase II study using laser-induced thermal therapy (LITT) as a palliative treatment for 106 patients with recurrent head and neck tumors.
Study Design: Retrospective study.
Setting: Tertiary hospital in the United States.
Subjects and Methods: The primary endpoints were tumor response and survival. Prognostic values were assessed by the Kaplan-Meier method.
Results: The best results were seen in oral cavity tumors, in which mean survival was 29.1 months, as compared to neck tumors (mean 14.4 +/- 6.9 months; range 7.5-20.7 months; with a 95% confidence interval). Further analysis showed that clinical factors such as gender, smoking, and alcohol use were not indicators of poor prognosis, whereas neck disease and tumor stage at first treatment were relevant factors.
Conclusion: In this study, 40 out of 106 patients treated by LITT remained alive at the end of our follow-up, and a complete response was seen in 24 (22.6%) patients. The highest response rate was seen in oral cavity tumors, which suggests that tumor location at this site may be a predictor of favorable outcome with LITT.
(Copyright 2010 American Academy of Otolaryngology-Head and Neck Surgery Foundation. Published by Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
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