Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein.

Autor: Murata Y; Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA. Yoshihiko_Murata@urmc.rochester.edu, Lightfoote PM, Falsey AR, Walsh EE
Jazyk: angličtina
Zdroj: Clinical and vaccine immunology : CVI [Clin Vaccine Immunol] 2010 Apr; Vol. 17 (4), pp. 695-7. Date of Electronic Publication: 2010 Feb 17.
DOI: 10.1128/CVI.00432-09
Abstrakt: We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera.
Databáze: MEDLINE