| Autor: |
Saidemberg DM; Laboratory of Structural Biology and Zoochemistry, Department of Biology/CEIS, Institute of Biosciences, São Paulo State University (UNESP), 13506-900, Rio Claro, SP, Brazil., da Silva-Filho LC, Tognoli LM, Tormena CF, Palma MS |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2010 Apr 23; Vol. 73 (4), pp. 527-31. |
| DOI: |
10.1021/np900424t |
| Abstrakt: |
Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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