Estimating the influenza vaccine effectiveness in elderly on a yearly basis using the Spanish influenza surveillance network--pilot case-control studies using different control groups, 2008-2009 season, Spain.

Autor: Savulescu C; European Centre for Disease Prevention and Control, European Programme for Intervention Epidemiology Training, Stockholm, Sweden. csavulescu@isciii.es, Valenciano M, de Mateo S, Larrauri A
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2010 Apr 01; Vol. 28 (16), pp. 2903-7. Date of Electronic Publication: 2010 Feb 11.
DOI: 10.1016/j.vaccine.2010.01.054
Abstrakt: We conducted a case-control and screening method studies to estimate influenza vaccine effectiveness (IVE) in the age group >or=65 years, based on the Spanish Influenza Sentinel Surveillance System (SISSS). Cases (influenza laboratory-confirmed) were compared to influenza-negative ILI patients (test-negative) and patients without ILI since the beginning of the season (non-ILI). For the screening method, cases' vaccination coverage was compared to the vaccination coverage of the GPs' catchment population. The results suggested a protective effect of the vaccine against laboratory-confirmed influenza in elderly in 2008-2009. The screening method and the test-negative control designs enable estimating IVE using exclusively SISSS data.
((c) 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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