The Cvt pathway as a model for selective autophagy.

Autor: Lynch-Day MA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA., Klionsky DJ
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2010 Apr 02; Vol. 584 (7), pp. 1359-66. Date of Electronic Publication: 2010 Feb 08.
DOI: 10.1016/j.febslet.2010.02.013
Abstrakt: Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms.
(Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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