The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.

Autor: Muñoz-Valle JF; Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. biologiamolecular@hotmail.com, Valle Y, Padilla-Gutiérrez JR, Parra-Rojas I, Rangel-Villalobos H, Vázquez del Mercado M, Ledezma-Lozano IY, Villafan-Bernal JR, Armendáriz-Borunda J, Pereira-Suárez AL
Jazyk: angličtina
Zdroj: Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 2010 May 02; Vol. 411 (9-10), pp. 725-8. Date of Electronic Publication: 2010 Feb 06.
DOI: 10.1016/j.cca.2010.02.001
Abstrakt: Background: The Cytotoxic T lymphocyte antigen (CTLA-4) is one of the major susceptibility genes associated with autoimmune diseases. Susceptibility to rheumatoid arthritis (RA) is determined by both environmental and genetic factors. The genetic contribution approaches 50-60%. The association between RA with the +49A>G CTLA-4 polymorphism in the Mexican population was investigated.
Methods: The polymerase chain reaction-restriction fragment was used to amplify the +49A>G CTLA-4 polymorphism in RA patients and healthy subjects (HS).
Results: We analyzed the association between the +49A>G CTLA-4 polymorphism and RA. The G allele frequency was higher in RA patients than HS (46.8 vs 37.7%, OR=1.45, p=0.01). RA patients carrying the A/G genotype were significantly more likely to be positive to CRP and RF. There was no evidence of an association between SNP genotypes and the clinical characteristics of rheumatoid arthritis.
Conclusions: The +49A>G CTLA-4 polymorphism is a genetic marker of susceptibility for RA in western Mexican population.
(Copyright 2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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