Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica.

Autor:	Robinson-Agramonte MA; International Center for Neurological Restoration and Cuban Neuroimmunology Society, Havana, Cuba. maria.robinson@infomed.sld.cu, Gonçalves CA, Portela LV, Saiz-Hinarejos A, Oses JP, Motta LS, Muller AP, Marquez Gonzalez ME, Souza DO
Jazyk:	angličtina
Zdroj:	Neuroimmunomodulation [Neuroimmunomodulation] 2010; Vol. 17 (3), pp. 177-9. Date of Electronic Publication: 2010 Feb 04.
DOI:	10.1159/000258717
Abstrakt:	Neuromyelitis optica (NMO), an uncommon central nervous system (CNS) demyelinating disease, produces transverse myelitis and severe optic neuritis. IgG-NMO autoantibody, a specific immunoglobulin binding aquaporin-4 water channel protein, confirms that NMO is a different entity to multiple sclerosis. Parallel to cytokine down-regulations found in serum of relapsing-NMO (rNMO) patients, it has been reported that IgG-NMO may also confer a worse course of the disease in r-NMO Caribbean patients. In this study, we were interested in exploring the influence of IgG-NMO autoantibody on S100beta levels and clinical parameters from serum of r-NMO patients. Serum samples from 24 rNMO patients and 10 controls were evaluated. The reduction of S100beta observed in r-NMO patients was not significant compared to controls; and no differences were present regarding IgG-NMO immunoreactivity. At the same time, a significant correlation was also observed between IgG-NMO autoantibody serum detection and EDSS (Expanded Disability Status Scale) in rNMO. These results corroborate a differential regulation of IgG-NMO autoantibodies on the S100beta glial marker and on the disability present in rNMO patients. (Copyright 2010 S. Karger AG, Basel.)
Databáze:	MEDLINE
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