| Autor: |
Ito S; Department of Hematology, Shizuoka Red Cross Hospital., Taguchi J, Kato J, Nakaya A, Tachibana T, Takemura S, Sano A, Ohata M, Ishigatsubo Y, Fujita H |
| Jazyk: |
japonština |
| Zdroj: |
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2010 Jan; Vol. 51 (1), pp. 69-73. |
| Abstrakt: |
Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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