| Autor: |
Alvarez Arias DA; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA., McCarty N, Lu L, Maldonado RA, Shinohara ML, Cantor H |
| Jazyk: |
angličtina |
| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2010 Feb 09; Vol. 107 (6), pp. 2556-61. Date of Electronic Publication: 2010 Jan 25. |
| DOI: |
10.1073/pnas.0913671107 |
| Abstrakt: |
Trafficking of transmembrane receptors to a specific intracellular compartment is conducted by adaptor molecules that bind to target motifs within the cytoplasmic domains of cargo proteins. We generated mice containing a lymphoid-specific deficiency of AP-1 using RNAi knockdown technology. Inhibition of AP-1 expression in thymocytes blocks progression from double-positive immature thymocytes, resulting in complete absence of CD4(+) single-positive thymocytes and severe reduction of CD3(+)CD8(+) single-positive thymocytes. Analysis of the contribution of AP-1 deficiency on the interaction between mature CD4(+) T cells and antigen-presenting cells revealed that AP-1 is essential to efficient immune synapse formation and associated T cell activation, suggesting a possible mechanism of AP-1 function in thymocyte development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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