Acinar cell carcinoma of the pancreas in a young patient with chronic pancreatitis.
| Autor: | Kebir FZ; Department of Pathology, Mongi Slim Hospital, 2046 Sidi Daoued La Marsa, Tunisia., Lahmar A, Arfa N, Manai S, El Ouaer MA, Bouraoui S, Gouttalier C, Mezabi-Regaya S |
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| Jazyk: | angličtina |
| Zdroj: | Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2010 Feb; Vol. 9 (1), pp. 103-6. |
| Abstrakt: | Background: Acinar cell carcinoma (ACC) is a rare malignancy of the pancreas arising from acinar cells. Unlike ductal adenocarcinoma, this tumor rarely presents with pancreatitis. Methods: We present a case of ACC associated with chronic calcifying pancreatitis, and a review of the literature focusing on diagnosis and management. Results: A 43-year-old man was proposed for Wirsungojejunal derivation for chronic pancreatitis. Histopathological examination of the tissue extracted revealed an ACC. Duodenopancreatectomy was performed. Six months post-operatively, the patient developed hepatic metastasis and was treated with gemcitabine as palliative chemotherapy. Conclusions: The clinical presentation of ACC of the pancreas is not specific and the tumor can be under-diagnosed when associated with chronic pancreatitis. Data regarding course, treatment, and prognosis of this tumor are generally lacking. |
| Databáze: | MEDLINE |
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