| Autor: |
Sarkaki A; Physiology Research Center, Department of Physiology, Faculty of Medicine, Ahvaz Jondishpour University of Medical Sciences, Ahvaz, Iran., Badavi M, Aligholi H, Moghaddam AZ |
| Jazyk: |
angličtina |
| Zdroj: |
Pakistan journal of biological sciences : PJBS [Pak J Biol Sci] 2009 Oct 15; Vol. 12 (20), pp. 1338-45. |
| DOI: |
10.3923/pjbs.2009.1338.1345 |
| Abstrakt: |
The aim of the present study was to investigate the preventive effect of 4 weeks soy meal (+/- isoflavone) on post-menopausal cognitive deficiency and body weight alteration in ovariectomized (OVX)-6-hydroxy dopamine (6-OHDA)-induced animal model of Parkinson's Disease (PD) which mimics status in menopause women. Female Wistar rats (250-300 g, 5-6 months old) were divided into 2 main groups. (1) Control; (2) OVX; included 5 subgroups that were pre-treated with 10 or 20 g soy with isoflavone in 30 g daily diet (10 and 20 groups, respectively), 10 or 20 g soy without isoflavone in 30 g daily diet (-10 and -20 groups, respectively) and 0 g soy (sham treated group) during 4 weeks after OVX. To induce animal model ofPD in main second group (OVX rats) the substantia nigra pars compacta (SNpc) was lesioned by 6-hydroxydopamine (6-OHDA) (8 microg kg(-1) 4 microL(-1) normal saline contains 0.1% ascorbate). All animals were trained in Morris water maze for evaluating the spatial learning and memory. The results indicated that pre-treatment of Parkinsonian rats with different doses of dietary soy meal (+/- isoflavone) improved the spatial learning and memory and prevents increasing the body weight after menopause significantly. Our data show that, long-duration dietary soy meal may have the potential neuroprotective effect against post-menopausal cognitive deficiency induced by degeneration of nigrostriatal dopaminergic system and constant body weight during post-menopausal life cycle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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