Serum tetranectin is a significant prognostic marker in ovarian cancer patients.
| Autor: | Begum FD; The Gynecologic Clinic, The Juliane Marie Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Høgdall E, Christensen IJ, Kjaer SK, Blaakaer J, Christensen L, Høgdall C |
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| Jazyk: | angličtina |
| Zdroj: | Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2010; Vol. 89 (2), pp. 190-8. |
| DOI: | 10.3109/00016340903530936 |
| Abstrakt: | Objective: To evaluate the prognostic value of preoperative serum tetranectin (TN) in Danish ovarian cancer (OvCa) patients. Design. Population-based, multidisciplinary Danish case-control study of OvCa. Participants: A total of 445 primary OvCa patients diagnosed at one of the gynecological departments in 18 regional hospitals around Denmark during the period 1994-1999. Methods: Serum levels of TN were evaluated preoperatively and tested for possible association with prognosis. Main Outcome Measures: Disease specific survival. Results: During the observation period (median 45.9 months, range 0.2-121) 278 OvCa-related deaths were seen. Univariate analysis of TN and CA125 demonstrated a significant association with survival using the Cox proportional hazards model, when stratified for adjuvant treatment (TN: p < 0.0001, hazard ratio = 0.44; 95% confidence interval 0.33-0.60 and CA125: p < 0.0001, hazard ratio = 1.19; 95% confidence interval 1.11-1.27). Disease specific survival curves for patients with tumors in the early stages showed no significant association with survival, neither for TN (p = 0.68) nor for CA125 (p = 0.07). For the stage III group, a significant association with survival was found for TN (p = 0.027), but not for CA125 (p = 0.37). Multivariate Cox analysis identified TN, age, residual tumor, International Federation of Gynecology and Obstetrics stage and grade but not serum CA125 as independent prognostic variables. Conclusion: Preoperative serum TN is a useful prognostic indicator of advanced stage for patients with OvCa. |
| Databáze: | MEDLINE |
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