Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study.

Autor:	MacCabe JH; Department of Psychiatry, Institute of Psychiatry, King's College London, London SE5 8AF, UK. j.maccabe@iop.kcl.ac.uk, Lambe MP, Cnattingius S, Sham PC, David AS, Reichenberg A, Murray RM, Hultman CM
Jazyk:	angličtina
Zdroj:	The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2010 Feb; Vol. 196 (2), pp. 109-15.
DOI:	10.1192/bjp.bp.108.060368
Abstrakt:	Background: Anecdotal and biographical reports suggest that bipolar disorder may be associated with high IQ or creativity, but evidence for any such connection is weak. Aims: To investigate possible associations between scholastic achievement and later bipolar disorder, using prospective data, in a whole-population cohort study. Method: Using individual school grades from all individuals finishing compulsory schooling in Sweden between 1988 and 1997, we tested associations between scholastic achievement at age 15-16 and hospital admission for psychosis between ages 17 and 31, adjusting for potential confounders. Results: Individuals with excellent school performance had a nearly fourfold increased risk of later bipolar disorder compared with those with average grades (hazard ratio HR = 3.79, 95% CI 2.11-6.82). This association appeared to be confined to males. Students with the poorest grades were also at moderately increased risk of bipolar disorder (HR = 1.86, 95% CI 1.06-3.28). Conclusions: These findings provide support for the hypothesis that exceptional intellectual ability is associated with bipolar disorder.
Databáze:	MEDLINE
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