| Autor: |
Fredrickson TN; Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Hartley JW, Morse HC 3rd |
| Jazyk: |
angličtina |
| Zdroj: |
Veterinary pathology [Vet Pathol] 2010 Mar; Vol. 47 (2), pp. 312-7. Date of Electronic Publication: 2010 Jan 29. |
| DOI: |
10.1177/0300985809358605 |
| Abstrakt: |
Over the period of a year, colitis was observed in 44 mice raised in a conventional nonspecific pathogen-free colony, 41 of these having concomitant retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS). The lesions varied from bacterial colonization to hyperplasia of colonic mucosa to severe, often fatal, ulceration. Citrobacter rodentium was isolated from the colon and/or liver of 2 mice with colitis. When C57BL/6 mice with or without MAIDS were given graded doses of the bacterium, only those with MAIDS developed colitis, and C rodentium was reisolated from their livers. Thus, mice with MAIDS can develop severe disease following opportunistic infection with an environmental contaminant of the colony that is nonpathogenic for normal adult mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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