First report of a human autochthonous hepatitis E virus infection in Brazil.
Autor: | Lopes Dos Santos DR; Laboratório de Desenvolvimento Tecnológico em Virologia, IOC, Fiocruz, Rio de Janeiro, Brazil. santosdl@ioc.fiocruz.br, Lewis-Ximenez LL, da Silva MF, de Sousa PS, Gaspar AM, Pinto MA |
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Jazyk: | angličtina |
Zdroj: | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2010 Mar; Vol. 47 (3), pp. 276-9. Date of Electronic Publication: 2010 Jan 29. |
DOI: | 10.1016/j.jcv.2009.12.021 |
Abstrakt: | Background: Sporadic acute hepatitis E cases occurring in non-endemic areas have been associated to genotypes 3 and 4 of hepatitis E virus. Several studies have demonstrated the relationship among human and animals strains, mostly pigs and deers, from respective areas characterizing zoonosis. Circulation of genotype 3 of HEV in Brazilian swine herds have already been demonstrated. Nevertheless, no confirmed human cases have been reported to date in Brazil. Objectives: A study was developed to attempt the identification of hepatitis E acute cases in Brazil. Study Design: A retrospective study carried out with 64 serum samples from patients with acute non-A-C hepatitis was performed to identify human cases of acute hepatitis E. Results: We could identify a confirmed case of acute hepatitis E. The patient seroconverted to hepatitis E virus-specific IgM and IgG antibody, HEV-RNA was amplified from serum, and the analysis of the sequence of a 242 nucleotide fragment from the ORF1 genome region classified the strain within genotype 3 and subgenotype 3b. Investigation of risk factors and results from phylogenetic analysis suggested a likely zoonotic origin for the infection. Conclusions: The first report of a human autochthonous in Brazil contributes with new information for hepatitis E epidemiology in Latin America and to considerate further broadly epidemiological studies. |
Databáze: | MEDLINE |
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