First report of a human autochthonous hepatitis E virus infection in Brazil.

Autor: Lopes Dos Santos DR; Laboratório de Desenvolvimento Tecnológico em Virologia, IOC, Fiocruz, Rio de Janeiro, Brazil. santosdl@ioc.fiocruz.br, Lewis-Ximenez LL, da Silva MF, de Sousa PS, Gaspar AM, Pinto MA
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2010 Mar; Vol. 47 (3), pp. 276-9. Date of Electronic Publication: 2010 Jan 29.
DOI: 10.1016/j.jcv.2009.12.021
Abstrakt: Background: Sporadic acute hepatitis E cases occurring in non-endemic areas have been associated to genotypes 3 and 4 of hepatitis E virus. Several studies have demonstrated the relationship among human and animals strains, mostly pigs and deers, from respective areas characterizing zoonosis. Circulation of genotype 3 of HEV in Brazilian swine herds have already been demonstrated. Nevertheless, no confirmed human cases have been reported to date in Brazil.
Objectives: A study was developed to attempt the identification of hepatitis E acute cases in Brazil.
Study Design: A retrospective study carried out with 64 serum samples from patients with acute non-A-C hepatitis was performed to identify human cases of acute hepatitis E.
Results: We could identify a confirmed case of acute hepatitis E. The patient seroconverted to hepatitis E virus-specific IgM and IgG antibody, HEV-RNA was amplified from serum, and the analysis of the sequence of a 242 nucleotide fragment from the ORF1 genome region classified the strain within genotype 3 and subgenotype 3b. Investigation of risk factors and results from phylogenetic analysis suggested a likely zoonotic origin for the infection.
Conclusions: The first report of a human autochthonous in Brazil contributes with new information for hepatitis E epidemiology in Latin America and to considerate further broadly epidemiological studies.
Databáze: MEDLINE
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