| Autor: |
de Sousa Luis JA; Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa-PB, CEP 58.051-970, Brazil., Barbosa Filho JM, Freitas Lira B, Almeida Medeiros I, Soares Lima de Morais LC, dos Anjos RM, Dos Santos AF, Soares de Oliveira C, de Athayde-Filho PF |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2009 Dec 30; Vol. 15 (1), pp. 128-37. Date of Electronic Publication: 2009 Dec 30. |
| DOI: |
10.3390/molecules15010128 |
| Abstrakt: |
Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of amino acids with C-phenylglycine, phenyl isocyanate and phenyl isothiocyanate. Four amino-derivatives IG(1-4) and eight imidazolidinic derivatives, IM(1-8), were obtained in yields of 70-74%. The mass, infrared, (1)H and (13)C-NMR spectra of representative products are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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