| Autor: |
Yaraee R; Department of Immunology, Medical Faculty, Medical School and Medicinal Plant Research Center, Shahed University, Tehran, Iran. ryaraee@yahoo.com, Naseri M, Eghtedardoost M, Ahmadi A |
| Jazyk: |
angličtina |
| Zdroj: |
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2010 Sep; Vol. 32 (3), pp. 450-3. |
| DOI: |
10.3109/08923970903513121 |
| Abstrakt: |
The tendency of immune response toward either Th1 or Th2 cytokine pattern can cause a number of pathologic conditions. Multiple sclerosis is postulated to be a Th1-type cell-mediated autoimmune disease. MS14--an Iranian natural product--seems to possess anti-inflammatory properties. Thus, we studied the effect of orally administered MS14 on Th2 cytokines (IL-5 and IL-10) in normal Balb/C mice (100 mg/kg; 5 days). The result indicated that activated splenocytes of MS14 group produced significantly more IL-5 and IL-10 (3-4 times in comparison with control group mice). MS14 could upregulate Th2 cytokine and thereby it may possess immunoregulatory properties probably useful in treatment of some diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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