| Autor: |
Jadoul M; Cliniques Universitaires St Luc, Université Catholique de Louvain , Brussels , Belgium., Baños A, Zani VJ, Hercz G |
| Jazyk: |
angličtina |
| Zdroj: |
NDT plus [NDT Plus] 2010 Feb; Vol. 3 (1), pp. 37-41. Date of Electronic Publication: 2009 Dec 04. |
| DOI: |
10.1093/ndtplus/sfp167 |
| Abstrakt: |
Background. The calcimimetic, cinacalcet, is approved for treating secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on dialysis. Biochemical profiles and clinical outcomes in patients discontinuing cinacalcet at kidney transplantation have not been previously described.Methods. We performed a retrospective observational study evaluating post-transplant biochemical profiles and clinical outcomes in patients who had enrolled in phase 2 or 3 randomized, placebo-controlled studies of cinacalcet before receiving a kidney transplant.Results. The study included 28 former cinacalcet and 10 former placebo patients. Post-kidney transplant, there were no obvious differences between the two groups in levels of serum intact parathyroid hormone, calcium or phosphorus. One patient in each group underwent post-transplant parathyroidectomy. Kidney transplant failure was apparent in one former cinacalcet-treated patient (4%) and three former placebo patients (30%). The duration of hospitalization (mean +/- standard error) immediately post-transplant in these two groups was 2.3 +/- 0.3 and 3.4 +/- 0.8 weeks, respectively.Conclusions. Using cinacalcet to treat SHPT in patients with CKD awaiting kidney transplantation does not appear to modify SHPT-related post-transplant biochemical profiles, or clinical outcomes, compared with placebo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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