| Autor: |
dos Santos AG; Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Química, São Paulo State University, CP 355, 14800-900, Araraquara-SP, Brazil., Ferreira PM, Vieira Júnior GM, Perez CC, Gomes Tininis A, Silva GH, Bolzani Vda S, Costa-Lotufo LV, Pessoa Cdo O, Cavalheiro AJ |
| Jazyk: |
angličtina |
| Zdroj: |
Chemistry & biodiversity [Chem Biodivers] 2010 Jan; Vol. 7 (1), pp. 205-15. |
| DOI: |
10.1002/cbdv.200800342 |
| Abstrakt: |
An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, casearin X, together with the known compounds casearins B, D, L, and O, and caseargrewiin F. Casearin X degraded to the corresponding dialdehyde when stored in CDCl(3). The diterpenes isolated were cytotoxic to human cancer cell lines, with caseargrewiin F being the most active and the new clerodane, casearin X, the second active compound with IC(50) values comparable to the positive control doxorubicin. All isolated diterpenes showed lower activities against normal human cells than against cancer cell lines, which might indicate a possible selective action on cancer cells. Casearin X dialdehyde was not cytotoxic to cancer cells indicating that the occurrence of these CO groups at C(18) and C(19) is incompatible with the cytotoxic activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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