Effect of in vitro culture of human embryos on birthweight of newborns.

Autor:	Dumoulin JC; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Center for Reproductive Medicine, Maastricht, The Netherlands. j.dumoulin@maastrichtuniversity.nl, Land JA, Van Montfoort AP, Nelissen EC, Coonen E, Derhaag JG, Schreurs IL, Dunselman GA, Kester AD, Geraedts JP, Evers JL
Jazyk:	angličtina
Zdroj:	Human reproduction (Oxford, England) [Hum Reprod] 2010 Mar; Vol. 25 (3), pp. 605-12. Date of Electronic Publication: 2010 Jan 18.
DOI:	10.1093/humrep/dep456
Abstrakt:	Background: In animal models, in vitro culture of preimplantation embryos has been shown to be a risk factor for abnormal fetal outcome, including high and low birthweight. In the human, mean birthweight of singletons after in vitro fertilization (IVF) is considerably lower than after natural conception, but it is not known whether culture conditions play a role in this. Methods: We compared pregnancy rates and perinatal outcomes from singleton pregnancies resulting from a total of 826 first IVF treatment cycles in which oocytes and embryos were randomly allocated to culture in either of two commercially available sequential media systems. Results: When the 110 live born singletons in the Vitrolife group were compared with the 78 singletons in the Cook group, birthweight +/- SEM (3453 +/- 53 versus 3208 +/- 61 g, P = 0.003), and birthweight adjusted for gestational age and gender (mean z-score +/- SEM: 0.13 +/- 0.09 versus -0.31 +/- 0.10, P = 0.001) were both significantly higher in the Vitrolife group. When analyzed by multiple linear regression together with several other variables that could possibly affect birthweight as covariates, the type of culture medium was significantly (P = 0.01) associated with birthweight. Conclusions: In vitro culture of human embryos can affect birthweight of live born singletons.
Databáze:	MEDLINE
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