Biochemical profile of dogs experimentally envenomed with Tityus serrulatus scorpion venom.

Autor: Ribeiro EL; Escola de Veterinária, Universidade Federal de Minas Gerais, Minas Gerais, Belo Horizonte, MG, Brazil., Pinto MC, Labarrère CR, Paes PR, Paes-Leme FO, Chávez-Olórtegui C, Melo MM
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2010 Jun 01; Vol. 55 (6), pp. 1125-31. Date of Electronic Publication: 2010 Jan 07.
DOI: 10.1016/j.toxicon.2010.01.001
Abstrakt: The aim of this study was to evaluate the canine blood and urinary profiles after envenomation by Tityus serrulatus venom. Twelve dogs were randomly distributed into two equal groups. Control group animals received 0.5 mL phosphate buffered saline (PBS) injected subcutaneously into the internal portion of the left thigh, whilst dogs in the envenomed group were injected with scorpion venom (250 microg/kg in 0.5 mL PBS). No significant alterations were detected in the urine of envenomed dogs. Levels of plasma glucose and serum urea, creatinine, total protein, potassium, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), and amylase were determined. Semi-quantitative analysis of serum cardiac troponin I (cTnI) was performed using an immunochromatographic test. The concentrations of cortisol and insulin were determined using commercial radioimmunoassay kits. Increases in serum cortisol levels in experimental group animals coincided with hyperglycaemia and was probably a response to pain. Increased insulin levels were observed during the hyperglycaemic peaks. Envenomed dogs presented discreet increases in ALT, AST and CK, but no alterations in LDH, amylase, cTnI, urea, creatinine and potassium levels were observed. It was concluded that the venom of T. serrulatus induces blood and urinary biochemical changes in dogs.
(Copyright 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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