| Autor: |
Quirk MC; Cold Spring Harbor Laboratory, Cold Spring Harbor NY, USA., Sosulski DL, Feierstein CE, Uchida N, Mainen ZF |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in systems neuroscience [Front Syst Neurosci] 2009 Nov 03; Vol. 3, pp. 13. Date of Electronic Publication: 2009 Nov 03 (Print Publication: 2009). |
| DOI: |
10.3389/neuro.06.013.2009 |
| Abstrakt: |
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
