| Autor: |
Maffezzini M; Department of Urology, Istituto Scientifico San Raffaele, Milano, Italy., Torelli T, Villa E, Corrada P, Bolognesi A, Leidi GL, Rigatti P, Campo B |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of urology [J Urol] 1991 Apr; Vol. 145 (4), pp. 741-3. |
| DOI: |
10.1016/s0022-5347(17)38440-9 |
| Abstrakt: |
A total of 44 patients with infiltrating, locally advanced bladder cancer (stages T 3a-b, T 4a-b and N+/N0) were treated with the systemic chemotherapy regimen of cisplatin, methotrexate and vinblastine (CMV) in the neoadjuvant setting, of whom 39 were evaluable for response. After planned radical cystectomy and 2 to 3 cycles of chemotherapy no tumor was found on the pathological specimen of 4 patients (10%), the tumor was downstaged in 19 (49%) and no change was observed in 16 (41%). Toxicity included leukopenia in 29 patients (66%), 1 of whom died of granulocytopenic sepsis, nausea and vomiting in 39 (89%) and mild to moderate mucositis in 18 (41%). Median followup is 12 months with a range of 6 to 39 months. Of 32 patients followed for longer than 6 months 6 (19%) experienced progression or recurrence of disease. We conclude that preoperative CMV chemotherapy is effective in inducing downstaging of the tumor, although systemic toxicity limits its use to cautiously selected patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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