| Autor: |
Berković MC; Department of Endocrinology, Diabetes and Metabolism, University Hospital Sestre milosrdnice, Vinogradska 29, 10000, Zagreb, Croatia. mberkovi@globalnet.hr, Jokić M, Marout J, Radosević S, Zjacić-Rotkvić V, Kapitanović S |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2010 Apr; Vol. 88 (4), pp. 423-9. Date of Electronic Publication: 2010 Jan 05. |
| DOI: |
10.1007/s00109-009-0581-x |
| Abstrakt: |
Cytokines participate in tumorigenesis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Single nucleotide polymorphisms (SNPs) in cytokine genes influence expression of proteins and are evaluated in cancer susceptibility. The aim of this study was to evaluate IL-2 -330 T/G SNP and susceptibility to GEP-NETs, and analyze the correlation between G-allele and IL-2 serum values in GEP-NET patients. Moreover we assessed the value of IL-2 as a tumor serum marker. IL-2 -330 T/G SNP was examined in 101 patients and 150 healthy volunteers and IL-2 serum levels in patients and 20 controls. Patients' IL-2 serum levels were compared to IL-2 -330 T/G genotypes and tumor functional status and finally with known markers such as chromogranin A (CgA) and 5-hydroxyindolacetic acid (5-HIAA). There was a significant difference in genotype distribution of the IL-2 -330 polymorphisms between GEP-NET and control group (p = 0.0006) as well as in the frequency of G-allele (p = 0.010). G-allele correlated with higher IL-2 serum levels (p = 0.028) and elevated in all patients, being highest in patients with functional tumors (p = 0.039). Compared to CgA and 5-HIAA, IL-2 was more specific in detecting GEP-NET patients (p < 0.0001 and p < 0.0001, respectively). Our results indicate importance of IL-2 in GEP-NET development and biochemical diagnosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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