Gd(III)-nanodiamond conjugates for MRI contrast enhancement.

Autor: Manus LM; Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA., Mastarone DJ, Waters EA, Zhang XQ, Schultz-Sikma EA, Macrenaris KW, Ho D, Meade TJ
Jazyk: angličtina
Zdroj: Nano letters [Nano Lett] 2010 Feb 10; Vol. 10 (2), pp. 484-9.
DOI: 10.1021/nl903264h
Abstrakt: A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T(1) of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.
Databáze: MEDLINE