Differential expression of respiratory long-term facilitation among inbred rat strains.

Autor: Baker-Herman TL; Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA. bakert@svm.vetmed.wisc.edu, Bavis RW, Dahlberg JM, Mitchell AZ, Wilkerson JE, Golder FJ, Macfarlane PM, Watters JJ, Behan M, Mitchell GS
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2010 Mar 31; Vol. 170 (3), pp. 260-7. Date of Electronic Publication: 2009 Dec 29.
DOI: 10.1016/j.resp.2009.12.008
Abstrakt: We tested the hypotheses that: (1) long-term facilitation (LTF) following acute intermittent hypoxia (AIH) varies among three inbred rat strains: Fischer 344 (F344), Brown Norway (BN) and Lewis rats and (2) ventral cervical spinal levels of genes important for phrenic LTF (pLTF) vary in association with pLTF magnitude. Lewis and F344, but not BN rats exhibited significant increases in phrenic and hypoglossal burst amplitude 60min post-AIH that were significantly greater than control experiments without AIH, indicating strain differences in phrenic (98%, 56% and 20%, respectively) and hypoglossal LTF (66%, 77% and 5%, respectively). Ventral spinal 5-HT(2A) receptor mRNA and protein levels were higher in F344 and Lewis versus BN, suggesting that higher 5-HT(2A) receptor levels are associated with greater pLTF. More complex relationships were found for 5-HT(7), BDNF and TrkB mRNA. BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF.
(Copyright 2009 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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