Leiomyoma shrinkage after MRI-guided focused ultrasound treatment: report of 80 patients.
| Autor: | LeBlang SD; Department of Radiology, University Imaging-Guided Therapy Center, 3848 FAU Blvd., Ste. 200, Boca Raton, FL 33431, USA. sleblang@universitymri.com, Hoctor K, Steinberg FL |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | AJR. American journal of roentgenology [AJR Am J Roentgenol] 2010 Jan; Vol. 194 (1), pp. 274-80. |
| DOI: | 10.2214/AJR.09.2842 |
| Abstrakt: | Objective: The purpose of this study was to assess the degree of leiomyoma ablation and shrinkage after MRI-guided focused ultrasound treatment performed according to U.S. Food and Drug Administration protocols for commercial trials. Materials and Methods: A total of 147 symptomatic leiomyomas in 80 women (average age, 46 years; range, 34-55 years) were managed with MRI-guided focused ultrasound. The average volume of treated fibroids was 175+/-201 (SD) cm3. Before treatment, T2-weighted MR images in three planes were obtained to measure leiomyoma volume. Immediately after treatment, T1-weighted contrast-enhanced fat-suppressed MR images in three planes were used to measure nonperfused volume ratio. Similar images obtained 6 months after treatment were used to determine leiomyoma shrinkage. Qualitative and quantitative relations between fibroid volume, nonperfused volume ratio at treatment, and 6-month shrinkage were measured. Results: The average nonperfused volume ratio was 55%+/-25% immediately after treatment. Six months after treatment, the average volume of treated fibroids had decreased to 112+/-141 cm3 (n=81) (p<0.0001) with an average volume reduction of 31%+/-28%. A linear regression model showed highly significant correlation between posttreatment nonperfused volume ratio and shrinkage at 6 months (p<0.0001). Conclusion: MRI-guided focused ultrasound therapy for leiomyoma can result in nonperfused volume ratio and shrinkage that exceed those in previous clinical trials because the treatment guidelines have been relaxed to allow a greater amount of tissue ablation. The results suggest that a larger nonperfused volume ratio can be achieved, resulting in greater shrinkage and improved relief of symptoms. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|