Evaluation of response in malignant tumors treated with the multitargeted tyrosine kinase inhibitor sorafenib: a multitechnique imaging assessment.
| Autor: | Maksimovic O; Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany., Schraml C, Hartmann JT, Bitzer M, Claussen CD, Pintoffl J, Horger M |
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| Jazyk: | angličtina |
| Zdroj: | AJR. American journal of roentgenology [AJR Am J Roentgenol] 2010 Jan; Vol. 194 (1), pp. 5-14. |
| DOI: | 10.2214/AJR.09.2744 |
| Abstrakt: | Objective: The purpose of this article is to illustrate the characteristic changes induced in different tumor types by the multitargeted tyrosine kinase inhibitor sorafenib. Conclusion: Sorafenib reduces tumor perfusion and thereby induces necrosis and often hemorrhage. Malignant tumors treated with sorafenib undergo both morphologic and functional changes; however, the morphologic changes are less frequent and inadequate for early evaluation of response. Therefore, imaging tools accurately assessing hemorrhage and decrease in tumor perfusion with subsequent necrosis should be the mainstay in monitoring targeted therapy agents. |
| Databáze: | MEDLINE |
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