Characteristics of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay.

Autor: Pardo L; Department of Bacteriology and Virology, Institute of Hygiene, School of Medicine, Universidad de la República, Alfredo Navarro, 3051 Montevideo, Uruguay., Machado V, Mollerach M, Mota MI, Tuchscherr LP, Gadea P, Gardella N, Sordelli DO, Vola M, Schelotto F, Varela G
Jazyk: angličtina
Zdroj: International journal of microbiology [Int J Microbiol] 2009; Vol. 2009, pp. 472126. Date of Electronic Publication: 2009 Oct 22.
DOI: 10.1155/2009/472126
Abstrakt: We analyzed 90 nonduplicates community-associated methicillin-resistant S. aureus (CA-MRSA) strains isolated from skin and soft-tissue infections. All strains were mecA positive. Twenty-four of the 90 strains showed inducible macrolide-lincosamide-streptogramin B resistance. All strains produced alpha-toxin; 96% and 100% of them displayed positive results for lukS-F and cna genes, respectively. Eigthy-five strains expressed capsular polysaccharide serotype 8. Six different pulsotypes were discriminated by pulsed-field gel electrophoresis (PFGE) and three predominant groups of CA-MRSA strains (1, 2, and 4) were identified, in agreement with phenotypic and genotypic characteristics. Strains of group 1 (pulsotype A, CP8+, and Panton-Valentine leukocidin (PVL)+) were the most frequently recovered and exhibited a PFGE band pattern identical to other CA-MRSA strains previously isolated in Uruguay and Brazil. Three years after the first local CA-MRSA report, these strains are still producing skin and soft-tissue infections demonstrating the stability over time of this community-associated emerging pathogen.
Databáze: MEDLINE