Human papillomavirus-associated oropharyngeal cancer: a new clinical entity.

Autor: Nguyen NP; Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA. namphong.nguyen@yahoo.com, Chi A, Nguyen LM, Ly BH, Karlsson U, Vinh-Hung V
Jazyk: angličtina
Zdroj: QJM : monthly journal of the Association of Physicians [QJM] 2010 Apr; Vol. 103 (4), pp. 229-36. Date of Electronic Publication: 2009 Dec 16.
DOI: 10.1093/qjmed/hcp176
Abstrakt: The incidence of oropharyngeal cancers is rising worldwide in both nonsmokers and nondrinkers. Epidemiology studies suggest a strong association between human papillomavirus (HPV) 16 infection, changing sexual behavior and cancer development. Despite initial presentation with locally advanced disease and poorly differentiated histology, HPV-associated oropharyngeal carcinoma is associated with a good prognosis because its response to chemotherapy and radiation. Clinicians should be aware of the risk of oropharyngeal cancer in young people to avoid unnecessary delay in diagnosis and treatment. A history of oral sex should be elicited in young patients with enlarged neck nodes and/or tonsillar masses.
Databáze: MEDLINE