Hyperphosphatemia after sodium phosphate laxatives in low risk patients: prospective study.
| Autor: | Casais MN; Department of Anesthesia, Preoperative Evaluation Section, Hospital Italiano de Buenos Aires, Rivadavia 4965, 9C, Buenos Aires, Argentina. marcela.casais@hospitalitaliano.org.ar, Rosa-Diez G, Pérez S, Mansilla EN, Bravo S, Bonofiglio FC |
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| Jazyk: | angličtina |
| Zdroj: | World journal of gastroenterology [World J Gastroenterol] 2009 Dec 21; Vol. 15 (47), pp. 5960-5. |
| DOI: | 10.3748/wjg.15.5960 |
| Abstrakt: | Aim: To establish the frequency of hyperphosphatemia following the administration of sodium phosphate laxatives in low-risk patients. Methods: One hundred consecutive ASA I-II individuals aged 35-74 years, who were undergoing colonic cleansing with oral sodium phosphate (OSP) before colonoscopy were recruited for this prospective study. Exclusion Criteria: congestive heart failure, chronic kidney disease, diabetes, liver cirrhosis, intestinal obstruction, decreased bowel motility, increased bowel permeability, and hyperparathyroidism. The day before colonoscopy, all the participants entered a 24-h period of diet that consisted of 4 L of clear fluids with sugar or honey and 90 mL (60 g) of OSP in two 45-mL doses, 5 h apart. Serum phosphate was measured before and after the administration of the laxative. Results: The main demographic data (mean +/- SD) were: age, 58.9 +/- 8.4 years; height, 163.8 +/- 8.6 cm; weight, 71 +/- 13 kg; body mass index, 26 +/- 4; women, 66%. Serum phosphate increased from 3.74 +/- 0.56 to 5.58 +/- 1.1 mg/dL, which surpassed the normal value (2.5-4.5 mg/dL) in 87% of the patients. The highest serum phosphate was 9.6 mg/dL. Urea and creatinine remained within normal limits. Post-treatment OSP serum phosphate concentration correlated inversely with glomerular filtration rate (P < 0.007, R(2) = 0.0755), total body water (P < 0.001, R(2) = 0.156) and weight (P < 0.013, R(2) = 0.0635). Conclusion: In low-risk, well-hydrated patients, the standard dose of OSP-laxative-induced hyperphosphatemia is related to body weight. |
| Databáze: | MEDLINE |
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